Endocrine Abstracts

Growth hormone releasing hormone (GHRH) is a neuropeptide mainly synthesised in the hypothalamus, known to exert a stimulatory effect on the synthesis and release of growth hormone (GH) from the pituitary via the activation of specific receptors. New data indicate that GHRH is also produced in both extrahypothalamic brain areas and in peripheral tissues. GHRH-receptor splice variants (SVs) have been found in several peripheral normal and neoplastic human tissues and mediate ef...

The hypothalamic hormone growth hormone-releasing hormone (GHRH), has been shown to function via its receptor splice variants as an autocrine/paracrine growth factor in normal and malignant cell lines and tissues, besides positively regulating growth hormone (GH) synthesis and secretion from the pituitary. Moreover, GHRH antagonists are known to suppress the proliferation of a wide variety of cancer cells through mechanisms yet to be fully elucidated. Aim of this study was to ...